According to Entertainment Weekly,
"Set in Detroit, Deadpool tells the story of Wade Wilson who is left with accelerated healing but all around messed up after he agrees to an experimental procedure. Now he’s on the loose to hunt down the people that did this to him."
Are you in need of holiday cheer? Rejoice! For #Deadpool's all new trailer is here! https://t.co/WPOqjaYQMO— Deadpool Movie (@deadpoolmovie) December 25, 2015