This episode (airing Tuesday, Sept. 30 at 9 p.m.) is titled 'Heavy is the Head', and we have a synopsis from the +ABC Television Network below.
Marvel’s Agents of S.H.I.E.L.D. stars Clark Gregg as Agent Phil Coulson, Ming-Na Wen as Agent Melinda May, Brett Dalton as Grant Ward, Chloe Bennet as Skye, Iain De Caestecker as Agent Leo Fitz, Elizabeth Henstridge as Agent Jemma Simmons and Nick Blood as Lance Hunter.
Guest starring are Kyle MacLachlan as The Doctor, B.J. Britt as Agent Antoine Triplett, Ruth Negga as Raina, Henry Simmons as Alphonso “Mack” Mackenzie, Adrian Pasdar as General Glenn Talbot, Simon Kassianides as Sunil Bakshi, Brian Patrick Wade as Carl Creel, Wilmer Calderon as Idaho, Carolina Espiro as waitress, Cutter Garcia as bartender and Danny Pierce as soldier.
Thanks to comicbook.com